IGF-1 LR3 1mg

Buy IGF-1 LR3 at Wholesale Peptide: Clinical Grade Quality

Research into insulin like growth factor mechanisms has come a long way in understanding cellular growth pathways. Scientists investigating these mechanisms need access to modified peptides like IGF-1 LR3, a synthetic analog with unique properties for research studies. When you need to buy igf 1 lr3 for your research, understanding the molecular characteristics, research applications and quality matters for successful results.

This guide covers the molecular structure, mechanism of action and research applications of IGF-1 LR3 and provides critical information on sourcing high quality research peptides from established suppliers like Wholesale Peptide.

Molecular Structure of IGF-1 LR3

IGF-1 LR3 is a modified version of human insulin like growth factor 1, with specific structural modifications that differentiate it from the native protein. The peptide has 83 amino acids compared to 70 in native IGF-1, making it a longer variant with more properties for research use.

Amino Sequence: Gly-Pro-Glu-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala

The structural modifications include two key changes that impact the peptide’s behavior in research:

• Long Arginine Extension: The addition of 13 extra amino acids at the N-terminus (sequence: MFPAMPLLSLFVN) is what gives the “Long” in the compound’s name
• Arginine Substitution: The replacement of glutamic acid with arginine at the third position is what gives the “Arg3” or “LR3” in the name

Key Molecular Properties:

Property	Value
Molecular Formula	C400H625N111O115S7
Molecular Weight	9117 g/mol
PubChem CID	16132418
CAS Number	946870-92-4
Amino Acid Length	83 residues

These modifications result in reduced binding to igf binding proteins which normally sequester IGF-1 in the blood and limit its bioavailability. Research has measured the half life of IGF-1 LR3 to be over 20 hours compared to minutes for native IGF-1 making it a great tool for long term studies.

Mechanism of Action

IGF-1 LR3 works through the same pathway as native insulin like growth factor 1 but with increased stability and duration of action. The peptide binds to IGF-1 receptors on various cell types including skeletal muscle, nerve, liver, kidney, lung and skin cells. This binding activates the tyrosine kinase insulin receptor pathway and downstream signaling cascades.

The primary mechanism involves activation of the PI3K/Akt/mTOR pathway which research has shown to be involved in:

• Protein synthesis in cells
• Cell proliferation and cell growth processes
• Glucose uptake and fat metabolism pathways
• Tissue repair and muscle regeneration mechanisms

Research suggests IGF-1 LR3 may promote both hypertrophy (enlargement of existing cells) and hyperplasia (formation of new cells) in experimental models. This dual action makes it different from compounds that only affect one of these growth mechanisms. The peptide’s low affinity for IGFBPs allows it to remain active in circulation longer and provides sustained effects that can be measured and analyzed over long periods.

Studies using sds page have verified the peptide’s ability to bind to target receptors and remain stable under different experimental conditions. The connection between receptor binding and downstream cellular responses has been well documented in vitro research.

Research Studies

Scientific research on IGF-1 LR3 has covered various research areas with studies examining its effects on cellular function, growth mechanisms and metabolic processes. Research has looked into applications in several key areas:

Growth and Development Research: Studies have investigated the peptide’s role in growth hormone related pathways, looking into how the modified structure affects cellular responses compared to native IGF I. Research suggests potential applications in understanding growth factor signaling in different tissue types.

Metabolic Studies: Investigations have looked into the compound’s effects on glucose metabolism and fat metabolism in experimental models. The peptide’s insulin like properties make it useful for research into metabolic pathways and nutrient utilization mechanisms.Cellular Biology Research: IGF-1 LR3 has been used to study cell proliferation, protein synthesis and tissue repair. The longer half life allows researchers to observe prolonged cellular responses in controlled conditions.

Aging Research: Some studies have looked into the peptide’s role in aging related cellular processes, how growth factor signaling changes over time and how modified peptides affect these pathways.

Data shows IGF-1 LR3 remains active across various conditions, making it a reliable tool for reproducible studies. The peptide has been tested under different storage conditions, proper handling protocols ensure consistent results.

Storage and Safety

Proper storage and handling of IGF-1 LR3 is critical to maintain peptide integrity and get reliable results. As a protein based compound the peptide requires specific conditions to stay stable and functional.

Storage Requirements:

• Lyophilized Form: Store at -20°C for long term
• Reconstituted Solutions: Store at 2-8°C and use within recommended time frame
• Protection: Keep away from light, heat and moisture
• Container: Use sterile containers to prevent contamination

Research institutions must have proper protocols for peptide handling including use of personal protective equipment and secure storage. The responsibility for handling lies with the research institution and staff should be trained in peptide safety procedures.

Temperature fluctuations can affect peptide stability so storage systems should be monitored and maintained according to protocols. Regular verification of storage conditions helps protect research materials and ensure consistent results.

Safety Considerations:

Lab personnel should be aware of the biological activity of IGF-1 LR3 and handle it accordingly. The compound should only be used in research settings with proper safety measures in place. Research protocols should include provisions for safe handling, disposal and emergency procedures.

Why Buy from Wholesale Peptide

When researchers need to buy igf 1 lr3 for their studies, choosing a reliable supplier is key to success. Wholesale Peptide offers several benefits to support your research:

Quality Assurance: Every batch is tested by third party using HPLC to verify purity and accuracy. This testing protocol ensures researchers get peptides that meet the specified quality standards for their research.

Research Compliance: All products are for research use only, clearly labeled and documented to meet institutional compliance requirements. The website provides information on proper use designations and regulatory status.

Shipping: Wholesale Peptide ships same day for orders placed before 1pm EST Monday through Friday, orders after 1pm EST or weekends ship the next business day. This helps researchers meet their experimental timelines.

Customer Support: 30 day money back guarantee, customers can return unopened products for a full refund of the purchase price. This shows confidence in product and customer service.

Documentation: Documentation included with every purchase, certificates of analysis and storage instructions. This helps research facilities keep records and handling protocols.

The company focuses on research applications so products are prepared and tested according to lab standards. Quality control is implemented throughout the production and testing process to deliver consistent results for research.

Products from Wholesale Peptide are for Research Use Only

All products sold by Wholesale Peptide are research chemicals only. This designation allows use of these compounds for in vitro laboratory testing and experimentation only. Human or veterinary use is strictly forbidden. These products are not food additives, cosmetics or any other consumer products and may not be misbranded, mislabeled or misused for other purposes.

Research institutions and individual researchers must acknowledge this designation and use products according to established research protocols. The responsibility for proper use lies entirely with the purchaser and all research must be conducted at their own risk and in accordance with institutional guidelines.

Products are not intended for any purpose beyond legitimate research applications. Customers must verify their institutional requirements and ensure compliance with all applicable regulations before making a purchase.

Shipping Policy of Wholesale Peptide

Wholesale Peptide ships same day for orders placed before 1pm EST Monday through Friday. Orders placed after 1pm EST or weekends will be shipped the next business day. This shipping schedule allows for timely delivery while maintaining proper handling of research peptides.

Satisfaction Guarantee

Wholesale Peptide offers 30 day money back guarantee on all products. Customers can return any unopened products for a full refund of the purchase price of the unused products. This guarantee shows the company’s confidence in product and customer service.

Third-Party Testing of Every Batch

Every batch of products sold by Wholesale Peptide is tested by third party using HPLC to ensure product purity and accuracy. This testing protocol gives researchers confidence in the quality and consistency of their research materials. Test results are available for review and can be provided to support institutional quality requirements.

The testing process includes molecular identity verification, purity assessment and contamination screening. These comprehensive tests ensure researchers get products that meet scientific standards for experimental use.

Conclusion

IGF-1 LR3 is a valuable research tool for scientists studying growth factor mechanisms, cellular signaling pathways and metabolic processes. Its modified structure provides enhanced stability and longer activity compared to native insulin like growth factor 1, making it perfect for long term studies.

When researchers buy igf 1 lr3, selecting a reputable supplier with proper quality control is crucial for success. Wholesale Peptide’s third party testing, research compliance and customer support provides the foundation for research applications.

The company focuses on research grade peptides and proper storage and handling protocols so scientists have access to high quality materials for their research. Whether studying cellular growth mechanisms, metabolic pathways or tissue repair processes, IGF-1 LR3 has unique properties that support various research objectives.

For labs looking for reliable research grade IGF-1 LR3, Wholesale Peptide provides the quality assurance, documentation and support services for professional research applications. All products are for research use only and supports compliance with regulatory requirements while advancing scientific understanding of growth factor biology.

References

1. Hill, R. A., Hunter, R. A., Lindsay, D. B., & Owens, P. C. (1999). Action of long(R3)-insulin-like growth factor-1 on protein metabolism in beef heifers. Domestic Animal Endocrinology, 16(4), 219–229. https://doi.org/10.1016/s0739-7240(99)00015-6
2. Conlon, M. A., & Kita, K. (2001). Porcine growth hormone and LongR(3)IGF-I can improve recovery from surgery-induced weight loss in guinea pigs. General and Comparative Endocrinology, 123(3), 332–336. https://doi.org/10.1006/gcen.2001.76743. Stremming, J., Heard, S., White, A., Chang, E. I., Shaw, S. C., Wesolowski, S. R., Jonker, S. S., Rozance, P. J., & Brown, L. D. (2021). IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus. American Journal of Physiology-Endocrinology and Metabolism, 320(3), E527–E538. https://doi.org/10.1152/ajpendo.00453.2020
3. Stremming, J., White, A., Donthi, A., Batt, D. G., Hetrick, B., Chang, E. I., Wesolowski, S. R., Seefeldt, M. B., McCurdy, C. E., & Rozance, P. J. (2022). Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep. Frontiers in Physiology, 13, 954948. https://doi.org/10.3389/fphys.2022.954948
4. Jonker, S. S., Giraud, G. D., Chang, E. I., Elman, M. R., & Louey, S. (2020). Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep. FASEB Journal, 34(8), 10041–10055. https://doi.org/10.1096/fj.202000215R
5. Peptide Sciences. IGF-1 LR3 1mg product information and research overview. Retrieved from https://www.peptidesciences.com/igf-1-lr3-1mg
6. SwissChems. IGF-1 LR3 1mg product details and research references. Retrieved from https://swisschems.is/product/igf-1-lr3-1mg-price-is-per-vial
7. Qkine. Recombinant human IGF-1 LR3 protein (Qk041) product specifications and research applications. Retrieved from https://qkine.com/product/recombinant-human-igf1-lr3-protein-qk0419. BOC Sciences. CAS 946870-92-4 IGF-1 LR3 research studies and product information. Retrieved from https://aapep.bocsci.com/product/igf-1-lr3-cas-946870-92-4-341985.html
8. Novus Biologicals. Recombinant Human IGF-I/IGF-1 LR3 Protein product description and assays. Retrieved from https://www.fishersci.at/shop/products/recombinant-human-igf-i-igf-1-lr3-protein-3/18640648

To learn more about IGF-1 LR3, please refer to Wikipedia.